Bioinformatics and computational biology involve the use of techniques from applied mathematics, informatics, statistics, and computer science, and chemistry, especially biochemistry to solve biological problems usually on the molecular level. Research in computational biology often overlaps with systems biology. Major research efforts in the field include sequence alignment, gene finding, genome assembly, protein structure alignment, protein structure prediction, prediction of gene expression and protein-protein interactions, and the modeling of evolution.

• Sequence analysis
• Measuring biodiversity
• Computational evolutionary biology
• Analysis of gene expression
• Analysis of regulation
• Analysis of protein expression
• Analysis of mutations in cancer
• Prediction of protein structure
• Comparative genomics
• Modeling biological systems
• High-throughput image analysis